By Peter Harris (auth.), Peter Harris, Philip A. Poole-Wilson (eds.)
The 11th global Congress of the overseas Society for center Re seek 1983 supplied a chance to study the various transforming into issues in our wisdom of the constitution and serve as of the myocardium. these on the assembly will bear in mind how London without warning went tropical. but aseries of scintillating studies held over 600 scientists captive within the lecture halls of Imperial collage. there have been classes on nuclear magnetic reso nance, the molecular foundation of electrophysiology, calmodulin, protein syn thesis and degradation, oxygen unfastened radicals, the structural parts of the myocyte, sarcolemmal sodium alternate, and the impact of lipids on membranes. the following now we have collected jointly, as quick as attainable, the various shows of the audio system invited to the symposia. they offer, we think, a extraordinary photograph ofthe range oftechnology and clinical enquiry which underlies this immensely energetic area of recent cardiology. If simply our scientific colleagues have been extra conscious of it! Peter Harris Philip A. Poole-Wilson London v Contents Evolution, Cardiac Failure, and Water Metabolism: Presidential handle . . . . . . . . . . . . . . . . . . .
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After amplification, detection, digitization, and signal-averaging, the spectrum is obtained from the fid by fast Fourier transformation. EFFECTS OF PERFUSION RATE AND EXTRACELLULAR PHOSPHATE ON CONTROL CONDITIONS We perfused our hearts with Tyrodes solution equilibrated with 95% O2 -5% CO 2 • The flow rate was established by observing the [PCr]/[ATP] 30 Peter Gordon Morris et al. 3 4 . 10 I o . ppm 5 I -10 . -20 Figure 1. 31p NMR spectrum of a ferret heart perfused in phosphate-free Tyrodes solution at 30°C.
1980. Measurement of ehanges in highenergy phosphates in the eardiae eycle using gated P-31 NMR. Proc. Natl. Acad. Sei. 77:3654-3658. 15. , and Morris, P. G. 1982. NMR Imaging in Biomedicine. Advances in Magnetic Resonance, Supplement 2. Aeademic Press, New York. 16. Matthews, P. , Williams, S. , Seymour, A. , Gadian, D. , and Radda, G. K. 1982. A phosphorus-31 NMR study ofsome metabolie and funetional effeets of the inotropie agents epinephrine and ouabain, and the ionophore R02-2985 (X537A) in the isolated perfused rat heart.